Cancer stem cells impact heterogeneity and uncertainty pdf

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cancer stem cells impact heterogeneity and uncertainty pdf

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It has been proposed that a subpopulation of tumour cells with stem cell-like characteristics, known as cancer stem cells CSCs , drives tumour initiation and generates tumour heterogeneity, thus leading to cancer metastasis, recurrence, and drug resistance. Although there has been substantial progress in CSC research into many solid tumour types, an understanding of the biology of CSCs in lung cancer remains elusive, mainly because of their heterogeneous origins and high plasticity. Here, we demonstrate that engineered lung cancer cells derived from normal human airway basal epithelial cells possessed CSC-like characteristics in terms of multilineage differentiation potential and strong tumour-initiating ability.

Cancer stem cells in the development of liver cancer

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Liver cancer is the second most common cause of cancer-related death. Every type of tumours including liver cancer contains cancer stem cells CSCs.

Cancer Stem Cells: From Historical Roots to a New Perspective

Oncotarget a primarily oncology-focused, peer-reviewed, open access, biweekly journal aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial , Introducing OncoTarget. Sponsored Conferences.

The identification of cancer stem cells CSCs that are responsible for tumor initiation, growth, metastasis, and therapeutic resistance might lead to a new thinking on cancer treatments. Similar to stem cells, CSCs also display high resistance to radiotherapy and chemotherapy with genotoxic agents. Thus, conventional therapy may shrink the tumor volume but cannot eliminate cancer. Eradiation of CSCs represents a novel therapeutic strategy. In addition to the protein kinases and enzymes that are involved in DDR, other processes that affect the DDR including chromatin remodeling should also be explored.

Cancer stem cells: impact, heterogeneity, and uncertainty.

The relationships between cancer and stemness have a long history that is traced here. From the midth century when the first theory on the embryonic origin of cancer was formulated to works on embryonal carcinoma cells in the midth century, many steps have been crossed leading to the current cancer stem cell theory postulating that tumor growth is supported by a small fraction of the tumoral cells that have stem-like properties. However, in the last fifteen years, many works regularly encourage us to revise the concept of cancer stem cell.

Cancer stem cells CSCs are subpopulations of cells with stem cell characteristics that produce both cancerous and non-tumorigenic cells in tumor tissues. The literature reports that CSCs are closely related to the development of hepatocellular carcinoma HCC and promote the malignant features of HCC such as high invasion, drug resistance, easy recurrence, easy metastasis, and poor prognosis. This review discusses the origin, molecular, and biological features, functions, and applications of CSCs in HCC in recent years; the goal is to clarify the importance of CSCs in treatment and explore their potential value in HCC-targeted therapy. CSCs have the capacity to self-renew and differentiate into heterogeneous tumor cells, which are responsible for the maintenance and propagation of the tumor Batlle and Clevers, Basing on this breakthrough, CSCs were subsequently found in a variety of hematopoietic cancer and solid tumors.

Tissues with defined cellular hierarchies in development and homeostasis give rise to tumors with cellular hierarchies, suggesting that tumors recapitulate specific tissues and mimic their origins. Glioblastoma GBM is the most prevalent and malignant primary brain tumor and contains self-renewing, tumorigenic cancer stem cells CSCs that contribute to tumor initiation and therapeutic resistance. As normal stem and progenitor cells participate in tissue development and repair, these developmental programs re-emerge in CSCs to support the development and progressive growth of tumors.

Metabolomic mapping of cancer stem cells for reducing and exploiting tumor heterogeneity

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Existence of cancer stem cells in hepatocellular carcinoma: myth or reality?

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A novel model of liver cancer stem cells developed from induced pluripotent stem cells

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