Toxoplasma gondii and schizophrenia pdf

Posted on Friday, April 30, 2021 1:20:41 AM Posted by Mohammed W. - 30.04.2021 and pdf, english pdf 4 Comments

toxoplasma gondii and schizophrenia pdf

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Toxoplasma gondii , an intracellular protozoan parasite, has a striking predilection for infecting the Central Nervous System and has been linked to an increased incidence of a number of psychiatric diseases. Several in vitro and in vivo studies have shown that T. These mechanisms underlying the neuropathology of latent toxoplasmosis seem to operate also in schizophrenia, supporting the link between the two disorders. Better understanding of the intricate parasite-neuroglial communications holds the key to unlocking the mystery of T.

Negative Effects of Latent Toxoplasmosis on Mental Health

This study was approved by the Ethical Committee of the University of Heidelberg. Robert H. We employed enzyme immunoassay EIA and Western blotting techniques to measure the level of antibodies to Toxoplasma gondii proteins in serum samples from 38 individuals undergoing their first episode of schizophrenia and from a group of matched control subjects. We found that the individuals with first-episode schizophrenia had significantly increased levels of IgG, IgM, and IgA class antibodies to Toxoplasma proteins, as compared with the control subjects. Schizophrenia is a serious neuropsychiatric disease of uncertain etiology. Family and twin studies indicate that there is a strong genetic component to the risk of acquiring schizophrenia.

Toxoplasma gondii is not only implicated in schizophrenia and related disorders, but also in Alzheimer's or Parkinson's disease, cancer, cardiac myopathies, and autoimmune disorders. Conditional protein knockdown, orchestrated by T. Susceptibility genes may thus be related to the causes and influencers of disease, rather than and as well as to the disease itself. The protozoan parasite Toxoplasma gondii T. It has been implicated in the pathogenesis of many diseases, most notably schizophrenia [ 6 — 8 ], but also with bipolar disorder [ 9 ] depression and suicide attempts [ 10 ]. It has already been noted that several schizophrenia susceptibility genes are related to the T. In animal models, and without the aid of any gene variant, such agents can, per se, induce pathological features relevant to the disease process, for example amyloid deposition and tau phosphorylation induced by herpes simplex, C.

Recent epidemiologic studies indicate that infectious agents may contribute to some cases of schizophrenia. In animals, infection with Toxoplasma gondii can alter behavior and neurotransmitter function. In humans, acute infection with T. Since , a total of 19 studies of T. Two other studies found that exposure to cats in childhood was a risk factor for the development of schizophrenia. Some medications used to treat schizophrenia inhibit the replication of T. Establishing the role of T.


Toxoplasmosis is a parasitic disease caused by Toxoplasma gondii , an apicomplexan. Toxoplasmosis is usually spread by eating poorly cooked food that contains cysts , exposure to infected cat feces, and from an infected mother to her baby during pregnancy. Prevention is by properly preparing and cooking food. Up to half of the world's population is infected by toxoplasmosis, but have no symptoms. Acute toxoplasmosis is often asymptomatic in healthy adults.

Metrics details. A Correction to this article was published on 23 June Toxoplasma multiplication and its persistence into the brain cause a local neuroinflammatory reaction, resulting synthesis of neurotransmitters involved in neurological disorders, especially schizophrenia. The Matrix metallopeptidase 9 MMP-9 protein can play a major role in this neuroinflammation. It can promote extravasation and migration of infected immune cells into the brain.

In humans, acute infection with T. gondii can produce psychotic symptoms similar to those displayed by persons with schizophrenia.

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